Orbitrap Excedion Mass Spectrometer

Thermo Scientific™ Orbitrap™ Excedion™ Mass Spectrometer combines quadrupole precursor selection, HCD fragmentation, and a high-field Orbitrap analyzer. This architecture delivers high-resolution MS and MS/MS data for compound identification, structural characterization, and quantitation in complex samples.

Enhanced Dynamic Range (eDR) technology extends the dynamic range within a resulting mass spectrum to five orders of magnitude under defined conditions. By acquiring data across mass subranges and automatically combining the results, the system supports the detection of low-abundance components alongside highly abundant compounds. This is particularly useful for metabolomic profiling and trace-contaminant detection.

The ion interface combines a high-capacity transfer tube and an electrodynamic ion funnel, optimized for efficient, gentle transmission of labile compounds. The OptaMax™ Plus ion source provides stable electrospray operation and flexibility across different LC flow rates. EASY-IC™ technology supplies internal reference ions for mass-scale correction during analysis.

The system supports targeted and untargeted data acquisition strategies. AcquireX™ enables automated reinjection workflows with updated precursor inclusion and exclusion lists. Compound Discoverer™ workflows complement the instrumentation with data processing for metabolomics and small-molecule identification.

Orbitrap Excedion can be upgraded in the laboratory to Orbitrap Excedion Pro, allowing analytical capabilities to expand as application requirements and research priorities evolve.

Orbitrap Excedion BioPharma configuration

Orbitrap Excedion BioPharma is a specialized configuration with an extended mass range up to m/z 8000. It includes Intact Protein and Oligonucleotide application modes, together with selectable ion-routing multipole pressure regimes for intact protein, oligonucleotide, and mRNA analysis. These capabilities are specific to the BioPharma configuration.