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MAbPac & ProPac Columns


Columns designed for high-resolution accurate mass analysis of monoclonal antibodies (mAbs), antibody drug
conjugates (ADCs) and other proteins using reversed-phase HPLC and LCMS for high-resolution separations.

 

Compatible with organic solvent used in HPLC and MS under RP conditions

  • Resin is based on a hydrophobic supermacroporous 4µm polymer particles
  • Stable at extreme pH (0 to 14) and high temperature (up to 110 °C)

 

Efficient with low carry over

  • 1,500Å large pore size polymeric resin
  • Efficient separation of protein molecules with very low carry over

 

Designed for reversed-phase biomolecule LC and LC/MS separations

  • Superior resolution power for monoclonal antibodies and related substances
  • High efficiency with low carry-over
  • Excellent MS compatibility
  • Wide operating pH range: 0 to 14
  • High temperature stability: up to 110°C
  • High throughput

 

ProPac columns are designed to address the regulatory requirements for biopharmaceutical characterization. The reproducible resin chemistry and manufacturing processes eliminate column variability as a concern in methods development and data analysis.

 

ProPac columns are available with weak or strong anion-exchange or cation-exchange resins packed in 2-, 4-, 9-, and 22-mm i.d. formats. The selectivity differences between the various resin types provide flexibility in maximizing the resolution of closely related proteins.

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